Endocrine Abstracts

Hyperleptinemia is associated with such risk factors for cardiovascular disease as insulin resistance, obesity and hypertension. Recently, it has been identified that leptin has prothrombotic properties and increases the accumulation of oxidant radicals in endothelial cells. It is hypothesized that leptin may be also one of the mediators promoting atherosclerosis.The objectives of the work were to:determine whether there are any co...